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Vascular normalization is regarded as an effective vascular-targeted therapeutic strategy [123](Fig

Oncogene 20 : 10631075 Slee EA, Keogh SA and Martin SJ (2000) Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysedby caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release

In the present study, Nrf2 levels were markedly downregulated due to the overproduction of ROS which led to the malfunction of the antioxidant defense mechanism resulting in a disturbance in the homeostasis of this antioxidant protein, and these results are supported by the findings deduced by Zhang et al